For which of the following should GPC cardholders ensure compliance?

GPC cardholders must ensure compliance with applicable regulations and policies because these guidelines are established to govern the use of government purchase cards. This compliance is crucial for maintaining fiscal responsibility, ensuring accountability, and adhering to the legal standards set forth for government spending. By following these regulations and policies, cardholders help safeguard government resources and prevent misuse of funds.

Adhering to only internal departmental guidelines may lead to a lack of uniformity and accountability across different divisions, whereas personal financial habits have no bearing on the compliance required for government-issued cards. Likewise, the preferences of vendors should not dictate cardholder compliance, as government spending must align with established regulations and not individual vendor interests. Thus, focusing on applicable regulations and policies ensures that cardholders operate within the framework needed to uphold integrity and efficiency in government purchasing operations.